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Echocardiograms for Translational Biomarker Development in Animals


New innovative and ground-breaking technologies are now being developed in the field of medical research. Vevo technology allows for echocardiograms for translational research and biomarker development in animals. This technological advancement provides a resolution down to 30 microns. Quantification tools and software are customized for small animal physiology. The high frame rate of acquisition provides the best spatial resolution and temporal specs compared to other imaging modalities such as CT and MRI. Today, medical researchers are now offered a variety of opportunities that until now were simply not possible.

Features of echocardiogram vevo technology for translational research and biomarker development include:

Quantitative evaluation of the cardiovascular system: Researchers will benefit from real-time quantification and evaluation of the functions of the developing heart and related major vessels. This includes right ventricular function, left ventricular function, blood flow, and valve movement.

Evaluation of cardiovascular disease and therapies: It is used in the evaluation of the extent of cardiovascular disease and measure the effectiveness of treatments. The non-invasive nature of the system allows medical professionals to study the effectiveness of treatment in the same animal over time. Examples of pathologies that can easily be assessed include: vessel stenosis, pulmonary hypertension, myocardial infarct, valvular regurgitation, diastolic dysfunction, atherosclerosis, cardiac hypertrophy, inflammation, and diabetes.

Evaluation of cardiovascular function in conscious mice: Hand-held probes allow imaging of conscious mice for assessing valvular disease at high frame rates. They are very lightweight and easy to handle.

Extensive measurement and annotation functionality: Vevo software provides measurement and annotation functionality that allows researchers to conduct all-inclusive analysis for measuring and monitoring and the progression of disease and the effectiveness of therapies. Examples of calculation packages include: fractional shortening, cardiac output, pulsatility indices and resistivity indices, quantification of ejection fraction, strain, and strain rate.

Monitoring of full animal physiology: Integrated Rail and Animal Handling Table allow physiological parameters to be captured and monitored during an imaging session such as heart rate, body temperature, respiration, and ECG.

Integration of blood pressure external devices: Researchers have the ability to integrate external blood pressure recordings with the Vevo system to acquire pressure volume data which is vital to stress-echo and pharmacological and studies.

Perform and visualize cardiac and vascular injections: An integrated rail system and image-guided needle injection system allow for precision adjustments to ensure a successful procedure. The Integrated Rail system allows for the precise position of a needle and syringe to be mounted and the animal to be carefully positioned on a heated table. The injection can be performed with minimal invasiveness thereby eliminating invasive surgical procedures and improves an animal’s survival.

The Vevo system is not just an important and essential system in the field of medical research, but it is also simple to use so that researchers can make the most of their time performing post-imaging analysis. As well, an offline workstation is available to analyze all data. Vevo technology provides echocardiograms for translational research and biomarker development in animal allowing researchers to gain valuable information that will benefit the medical industry and the search for better ways to diagnose disease and come up with better treatments.

The cutting-edge digital imaging company provides modalities designed for preclinical research, such as in vivo and molecular imaging. They specialize in the highest quality of biomarker, scientific digital imaging, and photoacoustic systems.